The insurgents detonated two suicide car bombs in Jobar district before trying to storm government defence lines, observers said.
Artillery shells and rockets landed inside the heart of the city as part of a surprise rebel attack, they say.
Last Wednesday, at least 31 people were killed in a suicide bomb attack at the main court complex in the centre of Damascus.
Image copyright AFP Image caption Rebel-held areas on the outskirts of Damascus have been extensively damaged in recent monthsSyrian security forces are engaged in fierce clashes with rebels on the eastern outskirts of the capital Damascus, residents say.
Deadly attack on Damascus court complexSyria`s war shows no sign of endingSix decisive points that changed Syria`s warRisking all to escapeDamascus only has a few opposition held areas, and Jobar is the closest to the city centre.
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